# Topics and Trends in Most Cited Advanced biosensing and bioanalysis techniques Papers, Class of 2026

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## What topics and trends defined most-cited Advanced biosensing and bioanalysis techniques research in the Class of 2026?

The Class of 2026 in advanced biosensing is driven by point-of-care testing, dual-mode detection, and MXene nanomaterials. Surface plasmon resonance and refractive index sensing surged alongside nanopore sequencing, while traditional gold nanoparticle assays declined as research shifted toward multi-modal diagnostics and clinical biomarker profiling.

## At a glance

| Fact | Value |
| --- | --- |
| Field | Advanced biosensing and bioanalysis techniques |
| Cohort label | Class of 2026 (2024 publications) |
| Papers analyzed | 19,051 |
| Papers ranked | 20 |
| Top topics in ranked papers | Point-of-care testing, electrochemical sensors, dual-mode detection, SPR sensing, MXene |
| Publication window | Jan 1, 2024 – Dec 31, 2024 |
| Eligibility | Research articles; reviews excluded |
| Citation window | 18 months post-publication |
| 18m citation range | 77–160 |
| Data source | OpenAlex · Retrieved Jul 2026 |
| License | CC BY 4.0 |

## Rankings

| Rank | Title | Authors | Corresponding authors | Affiliation | Journal | 18m citations | DOI |
| ---: | --- | --- | --- | --- | --- | ---: | --- |
| 1 | Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging | Yunsen Wang, Ruijin Zeng, Shuo Tian, Shuyun Chen, Zhilan Bi, Dianping Tang, Dietmar Knopp | Dianping Tang, Dietmar Knopp | Fuzhou University, China | Analytical Chemistry | 160 | 10.1021/acs.analchem.4c02606 |
| 2 | Design of Surface Plasmon Resonance (SPR) Sensors for Highly Sensitive Biomolecular Detection in Cancer Diagnostics | S Sasidevi, S. Kumarganesh, S Saranya, B. Thiyaneswaran, K V M Shree, Martin Sagayam K, Binay Kumar Pandey, Digvijay Pandey | Binay Kumar Pandey | Knowledge Institute of Technology, India | Plasmonics | 146 | 10.1007/s11468-024-02343-z |
| 3 | Pt/Zn-TCPP Nanozyme-Based Flexible Immunoassay for Dual-Mode Pressure–Temperature Monitoring of Low-Abundance Proteins | Di Wu, Juan Tang, Zhichao Yu, Yuan Gao, Yongyi Zeng, Dianping Tang, Xiaolong Liu | Dianping Tang, Xiaolong Liu | Fuzhou University, China | Analytical Chemistry | 116 | 10.1021/acs.analchem.4c01059 |
| 4 | Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain | Emily L Han, Sophia Tang, Dongyoon Kim, Amanda M Murray, Kelsey L Swingle, Alex G Hamilton, Kaitlin Mrksich, Marshall S Padilla, Rohan Palanki, Jacqueline J Li, Michael J Mitchell | Michael J. Mitchell | University of Pennsylvania, United States | Nano Letters | 113 | 10.1021/acs.nanolett.4c05186 |
| 5 | Multi-pass, single-molecule nanopore reading of long protein strands | Keisuke Motone, Daphne Kontogiorgos-Heintz, Jasmine Wee, Kyoko Kurihara, Sangbeom Yang, Gwendolin Roote, Oren E Fox, Yishu Fang, Melissa Queen, Mattias Tolhurst, Nicolas Cardozo, Miten Jain, Jeff Nivala | Jeff Nivala | University of Washington, United States | Nature | 111 | 10.1038/s41586-024-07935-7 |
| 6 | A self‐powered photoelectrochemical aptasensor using 3D‐carbon nitride and carbon‐based metal‐organic frameworks for high‐sensitivity detection of tetracycline in milk and water | Ying Dai, Wangui Peng, Yi Ji, Jia Wei, Junhao Che, Yongqiang Huang, Weihong Huang, Wenming Yang, Wanzhen Xu | Wenming Yang, Wanzhen Xu | Jiangsu University, China | Journal of Food Science | 107 | 10.1111/1750-3841.17398 |
| 7 | Self-designed portable dual-mode fluorescence device with custom python-based analysis software for rapid detection via dual-color FRET aptasensor with IoT capabilities | Chengquan Wang, Chengdong Gu, Xin Zhao, Shanshan Yu, Xiaorui Zhang, Foyan Xu, Lijun Ding, Xingyi Huang, Jing Qian | Chengquan Wang, Jing Qian | Jiangsu University, China | Food Chemistry | 102 | 10.1016/j.foodchem.2024.140190 |
| 8 | Ultrasensitive DNA Origami Plasmon Sensor for Accurate Detection in Circulating Tumor DNAs | Zhi Chen, Changle Meng, Xueliang Wang, Jiajie Chen, Jiefeng Deng, Taojian Fan, Lude Wang, Huiling Lin, Hao Huang, Shuang Li, Shuo Sun, Junle Qu, Dianyuan Fan, Xueji Zhang, Yingxia Liu, Yonghong Shao, Han Zhang | Yonghong Shao, Han Zhang | Shenzhen International Institute for Biomedical Research, China | Laser & Photonics Review | 98 | 10.1002/lpor.202400035 |
| 9 | Lamellar Ti3C2 MXene composite decorated with platinum-doped MoS2 nanosheets as electrochemical sensing functional platform for highly sensitive analysis of organophosphorus pesticides | Fei Wang, Yao Zhu, Long Qian, Yuhao Yin, Ziyu Yuan, Yuting Dai, Tao Zhang, Dongya Yang, Fengxian Qiu | Yao Zhu, Fengxian Qiu | Jiangsu University, China | Food Chemistry | 90 | 10.1016/j.foodchem.2024.140379 |
| 10 | Tuning sensitivity of bimetallic, MXene and graphene-based SPR biosensors for rapid malaria detection: a numerical approach | Bhishma Karki, Arun Uniyal, Manoj Sharma, Ram Bharos Yadav, Parusharamulu Buduma | Bhishma Karki | Tuljaram Chaturchand College Baramati, India | Journal of Computational Electronics | 90 | 10.1007/s10825-024-02191-4 |
| 11 | Ti3C2 MXene-based nanozyme as coreaction accelerator for enhancing electrochemiluminescence of glucose biosensing | Fatemeh Momeni, Seyyed Mehdi Khoshfetrat, Hasan Bagheri, Kobra Zarei | Seyyed Mehdi Khoshfetrat, Kobra Zarei | Damghan University, Iran | Biosensors and Bioelectronics | 87 | 10.1016/j.bios.2024.116078 |
| 12 | Zr‐MOF Carrier‐Enhanced Dual‐Mode Biosensing Platforms for Rapid and Sensitive Diagnosis of Mpox | Huiyi Yang, Judun Zheng, Wei Wang, Jingyan Lin, Jingru Wang, Lunjing Liu, Wenjie Wu, Chengli Zhang, Mingxia Zhang, Yu Fu, Bin Yang, Yuhui Liao | Mingxia Zhang, Yu Fu, Bin Yang, Yuhui Liao | Southern Medical University, China | Advanced Science | 87 | 10.1002/advs.202405848 |
| 13 | A bioswitchable delivery system for microRNA therapeutics based on a tetrahedral DNA nanostructure | Songhang Li, Taoran Tian, Tao Zhang, Yunfeng Lin, Xiaoxiao Cai | Xiaoxiao Cai | Sichuan University, China | Nature Protocols | 85 | 10.1038/s41596-024-01050-7 |
| 14 | Regulating Reactive Oxygen Species over M–N–C Single-Atom Catalysts for Potential-Resolved Electrochemiluminescence | Yan Zhou, Yu Wu, Zhen Luo, Ling Ling, Mengzhen Xi, Jingshuai Li, Liuyong Hu, Canglong Wang, Wenling Gu, Chengzhou Zhu | Liuyong Hu, Wenling Gu, Chengzhou Zhu | Central China Normal University, China | Journal of the American Chemical Society | 84 | 10.1021/jacs.4c02986 |
| 15 | A Mo2C/CoO@N/CNFs electrochemiluminescence sensor was prepared based on the electrospinning method for rapid detection of azithromycin | Jiayu Zhao, Hao Cheng, Jun Feng, Tingfan Tang, Danfeng Qin | Hao Cheng | Guangxi University of Science and Technology, China | Microchemical Journal | 84 | 10.1016/j.microc.2024.111241 |
| 16 | Multifunctional methyl orange-delaminated Ti3C2 MXene for non-enzymatic/metal-free electrochemical detection of hydrogen peroxide and hydrazine | Seyyed Mehdi Khoshfetrat, Maedeh Moradi, Hossein Zhaleh, Mehdi Hosseini | Seyyed Mehdi Khoshfetrat, Hossein Zhaleh | Ayatollah Boroujerdi University, Iran | Microchemical Journal | 82 | 10.1016/j.microc.2024.111382 |
| 17 | Plasmonic trimers designed as SERS-active chemical traps for subtyping of lung tumors | Xing Zhao, Xiaojing Liu, Dexiang Chen, Guodong Shi, Guoqun Li, Xiao Tang, Xiangnan Zhu, Mingze Li, Lei Yao, Yunjia Wei, Wenzhe Song, Zixuan Sun, Xingce Fan, Zhixin Zhou, Teng Qiu, Qi Hao | Teng Qiu, Qi Hao | Southeast University, China | Nature Communications | 79 | 10.1038/s41467-024-50321-0 |
| 18 | Gold nanoparticles in microelectronics advancements and biomedical applications | Mohamed Mohamady Ghobashy, Sh. A Alkhursani, Haifa A. Alqahtani, Tasneam K. El-damhougy, Mohamed Madani | Tasneam K. El-damhougy, Mohamed Madani | Atomic Energy Authority, Egypt | Materials Science and Engineering B | 77 | 10.1016/j.mseb.2024.117191 |
| 19 | Preparation of dual recognition adsorbents based on molecularly imprinted polymers and aptamer for highly sensitive recognition and enrichment of ochratoxin A | Lingjun Geng, Jingjing Liu, Wenbin Zhang, Haifang Wang, Jingcheng Huang, Guangxian Wang, Mengjiao Hu, Haowei Dong, Jiashuai Sun, Mingxuan Fang, Yemin Guo, Xia Sun | Jiashuai Sun, Yemin Guo, Xia Sun | Shandong University of Technology, China | Journal of Hazardous Materials | 77 | 10.1016/j.jhazmat.2024.135112 |
| 20 | Hybrid Plasmonic Biosensors with Deep Learning for Colorectal Cancer Detection | S. Kumarganesh, M. Murugesan, C Ganesh, N. Santhiyakumari, M. Thangavel, K.M.V. Jayaram, K. Martin Sagayam, Binay Kumar Pandey, Digvijay Pandey | Binay Kumar Pandey | Knowledge Institute of Technology, India | Plasmonics | 77 | 10.1007/s11468-024-02568-y |

## Topic trends

### What Topics Define the Class of 2026?

The Class of 2026 in advanced biosensing and bioanalysis is anchored by clinical translation, optical-electrochemical synergy, and nanomaterial innovation. Point-of-care testing leads the cohort, appearing in 16.0% of top-ranked publications as researchers prioritize decentralized, rapid diagnostic platforms for immediate clinical and field applications. Electrochemical sensors (14.0%) and surface plasmon resonance (SPR) sensing (12.0%) serve as primary transduction modalities, providing ultra-sensitive, label-free quantitative monitoring of target analytes. A key hallmark of this cohort is the rapid adoption of dual-mode detection platforms (14.0%), which integrate complementary signal channels—such as electrochemical-photothermal or optical-fluorescent readouts—to cross-verify diagnostic signals and drastically reduce false positives. Furthermore, advanced 2D nanomaterials, particularly Ti3C2 MXene and MXene nanocomposites (8.0%), have emerged as essential electrode modifiers due to their superior metallic conductivity, hydrophilic surfaces, and high catalytic active sites. Coupled with electrochemiluminescence and nanopore sequencing platforms (6.0%), these bioanalysis techniques collectively emphasize portable, highly specific, and multi-analyte biosensors capable of robust performance in complex biological matrices.

*Leading research themes*

### How Did Topics Shift from the Class of 2025 to the Class of 2026?

The transition from the Class of 2025 to the Class of 2026 reveals a significant evolution from traditional single-modality assays toward multi-modal transduction and next-generation nanomaterials. Emerging optical and physical detection techniques experienced the sharpest surge: refractive index sensing and nanopore sequencing entered the top tier from near-zero baseline mentions in 2023, reflecting growing interest in single-molecule resolution and real-time physical bio-interfacing. Surface plasmon resonance (SPR) sensing doubled its presence (fold change 2.0x), while dual-mode detection rose by 75%, reflecting a field-wide movement toward orthogonal validation mechanisms. Material choices also underwent a decisive shift: Ti3C2 MXene and MXene derivatives expanded 4-fold as functional electrocatalytic scaffolds. Conversely, classic signal amplifiers saw reduced dominance; gold nanoparticles experienced a sharp contraction from 10 mentions (20.0%) down to 3 mentions (6.0%), as researchers transitioned toward enzyme-mimicking nanozymes and engineered 2D nanocomposites. Furthermore, target applications shifted away from routine food safety analysis (dropping 40%) toward high-value clinical biomarker profiling and rapid point-of-care diagnostic platforms.

*How topics shifted year over year*

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Advanced biosensing and bioanalysis techniques Papers, Class of 2026. https://pri.pepkio.com/top-papers/advanced-biosensing-and-bioanalysis-techniques/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```