# Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity

*PRI Rank #8 · Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 81 |
| Journal | Cell Metabolism |
| Year | 2024 |
| DOI | 10.1016/j.cmet.2024.09.012 |
| Corresponding authors | Christoph Buettner |
| Institution | Rutgers Robert Wood Johnson Medical School, United States |

**Ranking page:** [Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026](https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026)

**Paper link:** [10.1016/j.cmet.2024.09.012](https://doi.org/10.1016/j.cmet.2024.09.012)

## Topics

overnutrition · insulin resistance · Metabolic dysfunction · sympathetic nervous system activity · sympathetic hyperactivity · glucose homeostasis · sympathetic outflow · Metabolic dysfunction · autonomic nervous system · diet-induced obesity · catecholamine signaling · adrenergic receptors · sympathetic denervation · metabolic syndrome · neuronal regulation of metabolism

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026. https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```