# Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation

*PRI Rank #6 · Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 134 |
| Journal | Cell Research |
| Year | 2024 |
| DOI | 10.1038/s41422-023-00864-6 |
| Corresponding authors | Wei Xu, Shimin Zhao |
| Institution | The Obstetrics & Gynecology Hospital of Fudan University, China |

**Ranking page:** [Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026](https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026)

**Paper link:** [10.1038/s41422-023-00864-6](https://doi.org/10.1038/s41422-023-00864-6)

## Topics

mitochondrial protein lactylation · Oxidative phosphorylation · physiological hypoxia · AARS2 · AARS2 · lysine lactyltransferase · PHD2 · proline 377 hydroxylation · proteasomal degradation · PDHA1 · pyruvate dehydrogenase complex · PDHA1 lysine 336 lactylation · CPT2 · carnitine palmitoyltransferase 2 · CPT2 lysine 457/458 lactylation · SIRT3 · acetyl-CoA influx · Fatty acid β-oxidation · lactate oxidation · exercise-induced hypoxia

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026. https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```