# Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

*PRI Rank #4 · Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 173 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07701-9 |
| Corresponding authors | Anissa A. Widjaja, Stuart A. Cook |
| Institution | Duke-National University of Singapore Medical School, Singapore |

**Ranking page:** [Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026](https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026)

**Paper link:** [10.1038/s41586-024-07701-9](https://doi.org/10.1038/s41586-024-07701-9)

## Topics

IL-11 · IL-11 signalling · IL11ra1 · ERK-AMPK-mTORC1 axis · metabolic decline · multi-morbidity · frailty · Aging biomarker · anti-IL-11 therapy · genetic deletion · lifespan extension · Healthspan · pro-inflammatory cytokine · IL-6 family · muscle function · fibrotic lung disease · Aging · tissue-level ageing · organismal-level ageing

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026. https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```