# Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake

*PRI Rank #16 · Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 62 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08108-2 |
| Corresponding authors | Jeffrey M. Friedman |
| Institution | The Rockefeller University, United States |

**Ranking page:** [Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026](https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026)

**Paper link:** [10.1038/s41586-024-08108-2](https://doi.org/10.1038/s41586-024-08108-2)

## Topics

leptin · BNC2 neurons · basonuclin 2 · Feeding suppression · AGRP neurons · agouti-related protein · POMC neurons · pro-opiomelanocortin · arcuate nucleus · leptin receptors · appetite regulation · place preference · positive valence · sensory food cues · nutritional status · hyperphagia · Obesity · Energy balance · neural circuit · leptin receptor knockout

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026. https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```