# Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia

*PRI Rank #13 · Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 72 |
| Journal | Nature Metabolism |
| Year | 2024 |
| DOI | 10.1038/s42255-024-00997-x |
| Corresponding authors | Vincenzo Sorrentino, Jérôme N. Feige |
| Institution | Nestlé Research, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026](https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026)

**Paper link:** [10.1038/s42255-024-00997-x](https://doi.org/10.1038/s42255-024-00997-x)

## Topics

trigonelline · NAD+ precursor · Muscle wasting · mitochondrial dysfunction · skeletal muscle ageing · nicotinic acid · Caenorhabditis elegans · primary myotubes · GPR109A · nicotinate phosphoribosyltransferase · Preiss–Handler pathway · Oxidative metabolism · mitochondrial biogenesis · Muscle wasting · sirtuin · muscle strength · Oxidative phosphorylation · serum trigonelline levels · isotopically labelled trigonelline · dietary supplementation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Adipose Tissue and Metabolism Papers, Class of 2026. https://pri.pepkio.com/top-papers/adipose-tissue-and-metabolism/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```