# RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

*PRI Rank #7 · Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 76 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08137-x |
| Corresponding authors | Eirini P. Papapetrou |
| Institution | Icahn School of Medicine at Mount Sinai, United States |

**Ranking page:** [Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026)

**Paper link:** [10.1038/s41586-024-08137-x](https://doi.org/10.1038/s41586-024-08137-x)

## Topics

RAS mutations · Acute myeloid leukemia (AML) · leukaemia stem cells · Venetoclax · Venetoclax · granulocyte–monocyte progenitors · monocytic disease · Clonal evolution · BCL2 family gene expression · relapsed/refractory disease · Driver mutations · temporal acquisition patterns · committed progenitors · haematopoietic hierarchy · Therapy resistance · myelomonocytic lineage · LSC target cell restriction

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```