# Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones

*PRI Rank #16 · Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 40 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-52980-5 |
| Corresponding authors | Tero Aittokallio |
| Institution | University of Helsinki, Finland |

**Ranking page:** [Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026)

**Paper link:** [10.1038/s41467-024-52980-5](https://doi.org/10.1038/s41467-024-52980-5)

## Topics

scTherapy · Single-cell RNA sequencing · intratumoral heterogeneity · multi-targeting therapies · Personalized treatment regimens · Acute myeloid leukemia (AML) · high-grade serous ovarian carcinoma · cancer clones · drug synergy · Drug resistance mechanisms · selective co-inhibition · machine learning prediction · primary patient cells · normal cell toxicity · Personalized treatment regimens · Hematologic malignancies · solid tumors · combinatorial drug screening · pan-cancer analysis · pathway co-inhibitors

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```