# A new genomic framework to categorize pediatric acute myeloid leukemia

*PRI Rank #13 · Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 50 |
| Journal | Nature Genetics |
| Year | 2024 |
| DOI | 10.1038/s41588-023-01640-3 |
| Corresponding authors | Jeffery M. Klco |
| Institution | St. Jude Children's Research Hospital, United States |

**Ranking page:** [Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026)

**Paper link:** [10.1038/s41588-023-01640-3](https://doi.org/10.1038/s41588-023-01640-3)

## Topics

Pediatric AML · pAML genomic landscape · Molecular classification · UBTF · BCL11B · HOXA expression signature · HOXB expression signature · RAS pathway genes · FLT3 · WT1 · mutational patterns · expression profiles · Measurable residual disease (MRD) · prognostic framework · pediatric-specific driver alterations

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```