# Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis

*PRI Rank #10 · Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 59 |
| Journal | Nature Genetics |
| Year | 2024 |
| DOI | 10.1038/s41588-024-01755-1 |
| Corresponding authors | Robert L. Cohen, Jyoti Nangalia |
| Institution | Calico Life Sciences LLC, United States |

**Ranking page:** [Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026)

**Paper link:** [10.1038/s41588-024-01755-1](https://doi.org/10.1038/s41588-024-01755-1)

## Topics

Clonal hematopoiesis · somatic mutations · positive selection · UK Biobank · Whole exome sequencing · ZBTB33 · ZNF318 · ZNF234 · SPRED2 · SH2B3 · SRCAP · SIK3 · SRSF1 · CHEK2 · CCDC115 · CCL22 · BAX · YLPM1 · MYD88 · MTA2

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Acute Myeloid Leukemia Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/acute-myeloid-leukemia-research/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```